Bacterial signalling overrides cytokine signalling and modifies dendritic cell differentiation

Muscle Differentiation: Signalling Cell Fusion

Myoblast fusion is fundamental both to the production of skeletal muscle during development and to its repair later in life. An in-depth knowledge of cell fusion in general, and myoblast fusion in particular, may also become crucial to developing clinical approaches to tissue repair based on stem cells and/or gene therapy [1,2]. But despite its importance, much remains to be learnt about cell f...

Cell-signalling repression in bacterial quorum sensing.

In this paper we expand on two mathematical models for investigating the role of three distinct repression mechanisms within the so-called quorum sensing (QS) cell-signalling process of bacterial colonies growing (1) in liquid cultures and (2) in biofilms. The repression mechanisms studied are (i) reduction of cell signalling molecule (QSM) production by a constitutively produced agent degradin...

Wnt Signalling During F9 Cell Differentiation

Dendritic signalling and homeostatic adaptation.

Homeostatic plasticity mechanisms are employed by neurons to alter membrane excitability and synaptic strength to adapt to changes in network activity. Recent studies suggest that homeostatic processes can occur not only on a global scale but also within specific neuronal subcompartments, involving a wide range of molecules and signalling pathways. Here, we review new findings into homeostatic ...

p38 MAPK and PI3K/AKT signalling cascades in Parkinson’s disease

Parkinson's disease (PD) is a chronic neurodegenerative condition which has the second largest incidence rate among all other neurodegenerative disorders barring Alzheimer's disease (AD). Currently there is no cure and researchers continue to probe the therapeutic prospect in cell cultures and animal models of PD. Out of several factors contributing to PD prognosis, the role of p38 MAPKs (mitog...